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  • Title: A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence.
    Author: Edenberg HJ, Reynolds J, Koller DL, Begleiter H, Bucholz KK, Conneally PM, Crowe R, Goate A, Hesselbrock V, Li TK, Nurnberger JI, Porjesz B, Reich T, Rice JP, Schuckit M, Tischfield JA, Foroud T.
    Journal: Alcohol Clin Exp Res; 1998 Aug; 22(5):1080-5. PubMed ID: 9726278.
    Abstract:
    A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families had at least three first-degree relatives who were alcohol-dependent. Analyses focused on individuals defined as alcohol-dependent by criteria from ICD-10 and on subsets of these individuals reporting withdrawal-related symptoms. Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring. We also report that African Americans differ from Caucasians in allele frequencies for this polymorphism.
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