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  • Title: A p56lck-independent pathway of CD2 signaling involves Jun kinase.
    Author: Sunder-Plassmann R, Reinherz EL.
    Journal: J Biol Chem; 1998 Sep 11; 273(37):24249-57. PubMed ID: 9727049.
    Abstract:
    The p56 Src family non-receptor tyrosine kinase has been shown to be critical for T lymphocyte differentiation and activation. Hence in the absence of p56, T cell receptor triggered activation does not occur. We now provide evidence for a CD2-based signaling pathway which, in contrast to that of the T cell receptor, is independent of p56. CD2-mediated interleukin-2 production occurs via activation of Jun kinase in cell lines lacking p56. Jun kinase then facilitates the binding of c-Jun/c-Fos heterodimers to the AP-1 consensus site and the subsequent transcriptional activity of the interleukin-2 promoter. These data elucidate differences between TCR and CD2 signaling pathways in the same T cells.
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