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  • Title: New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation.
    Author: Kimura K, Ikeda Y, Kagami S, Yoshihama M, Ubukata M, Esumi Y, Osada H, Isono K.
    Journal: J Antibiot (Tokyo); 1998 Jul; 51(7):647-54. PubMed ID: 9727391.
    Abstract:
    Various new liposidomycins were isolated from a culture of the strain Streptomyces sp. SN-1061M by changing medium components and they were classified into four types (I-IV) based on their structures. They were purified by butanol extraction, silica gel and LH-20 column chromatographies, and high performance liquid chromatography on ODS columns. Type (I) has the original structure which has sulfate and 3-methylglutaric acid moieties. Type (II) has no 3-methylglutaric acid moiety and type (III) has no sulfate moiety. Type (IV) has neither moiety. Type (III) and (IV) compounds, which have no sulfate moiety, exhibited more potent antimicrobial activity.
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