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  • Title: Gastrointestinal leiomyosarcomas: experience of 14 cases and review of published reports.
    Author: Papagrigoriadis S, Papadopoulou P, Kolias V, Panagiotidis H, Loizou M.
    Journal: Eur J Surg; 1998 Sep; 164(9):693-6. PubMed ID: 9728789.
    Abstract:
    OBJECTIVE: To present our experience of leiomyosarcoma of the gastrointestinal tract during a 10 year period and review similar publications. DESIGN: Retrospective study. SETTING: Teaching hospital, Greece. SUBJECTS: 14 patients who were treated for leiomyosarcoma between 1983 and 1993. INTERVENTIONS: Tumours were diagnosed by endoscopy, computed tomography, and contrast examination. All patients were treated by resection and no adjuvant treatment was given. MAIN OUTCOME MEASURES: Morbidity, mortality, and outcome. RESULTS: The diagnosis was made preoperatively in 10/14 patients: 4 of the tumours were locally advanced at the time of laparotomy, and two had liver metastases. Resection was potentially curative (all macroscopic tumour removed) in 12 patients (86%). Three patients died of recurrent disease at 5, 8 and 63 months, respectively. The mean follow up in the 11 survivors was 44 months (range 24-83). CONCLUSION: Resection is the treatment of choice for these tumours. A multicentre trial would be required to assess the effect of adjuvant chemotherapy.
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