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  • Title: Gene expression of the P2X receptors in the rat retina.
    Author: Brändle U, Guenther E, Irrle C, Wheeler-Schilling TH.
    Journal: Brain Res Mol Brain Res; 1998 Aug 31; 59(2):269-72. PubMed ID: 9729423.
    Abstract:
    Molecular-biological methods were used to demonstrate the expression of six P2X receptor subunits (P2X1-P2X6) in retina and choroid. Despite the considerable evidence for signalling by extracellular nucleotides in other sensory systems, few studies have been undertaken in the eye. RT-PCR for the detection of P2X subunit mRNA in the rat of different postnatal developmental stages (P23-P210) revealed the presence of P2X2 and P2X4 mRNA in the retina and choroid; P2X3, and P2X5 were detected only in the retina. There was no evidence for P2X1 and P2X6 mRNA in the ocular tissue under investigation. Our data suggest that extracellular ATP may have influences on visual processing.
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