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  • Title: Glabracins A and B, two new acetogenins from Annona glabra.
    Author: Liu XX, Alali FQ, Hopp DC, Rogers LL, Pilarinou E, McLaughlin JL.
    Journal: Bioorg Med Chem; 1998 Jul; 6(7):959-65. PubMed ID: 9730231.
    Abstract:
    Two new bioactive bis-THF Annonaceous acetogenins, glabracins A (1) and B (2), and two previously known acetogenins, javoricin (3) and bullatanocin (4), have been isolated from the leaves of Annona glabra by activity-directed fractionation using the brine shrimp lethality test (BST). The structures of 1 and 2 were elucidated based on spectroscopic and chemical methods, and the absolute stereochemistries were partially determined by the advanced Mosher ester method. 1 and 2 showed selective cytotoxicities to certain human tumor cell lines, and 1 was significantly more potent although 1 and 2 differ only in the stereochemistry of their vicinal diols at C-23/24.
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