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  • Title: Malignancy in pigmented villonodular synovitis.
    Author: Kalil RK, Unni KK.
    Journal: Skeletal Radiol; 1998 Jul; 27(7):392-5. PubMed ID: 9730332.
    Abstract:
    Malignant pigmented villonodular synovitis is an extremely rare and controversial disease. We describe malignant change in pigmented villonodular synovitis of the ankle in a patient with an unusually long clinical history. Symptoms began at age 21, metastatic disease developed at age 85, and the patient died 1 year later. The histologic appearance of the malignant tumor differed from that in most reported cases, in that spindle-shaped cells predominated. Lymph node metastasis also developed, a feature uncommon to soft tissue sarcomas.
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