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  • Title: Bcl-2 is located predominantly in the inner membrane and crista of mitochondria in rat liver.
    Author: Motoyama S, Kitamura M, Saito S, Minamiya Y, Suzuki H, Saito R, Terada K, Ogawa J, Inaba H.
    Journal: Biochem Biophys Res Commun; 1998 Aug 28; 249(3):628-36. PubMed ID: 9731187.
    Abstract:
    Bcl-2 is now recognized as a potent inhibitor of apoptotic cell death. It has been reported that Bcl-2 is located in the mitochondria, endoplasmic reticulum, and nuclear membrane in some cell lines, and it is not expressed in normal human and rat liver. An earlier study showed that Bcl-2 is an inner mitochondrial membrane protein. On the contrary, the following investigations using immunoelectron microscopy demonstrated that Bcl-2 resides predominantly in the mitochondrial outer membrane. In this study, using a cryo-sectioning immunogold labeling technique and immunoblotting, we carefully determined the subcellular localization of Bcl-2. Here we report that Bcl-2 is expressed in normal rat liver, and it is located predominantly in the inner membrane and crista rather than in the outer membrane of mitochondria.
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