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  • Title: An atomic model of fimbrin binding to F-actin and its implications for filament crosslinking and regulation.
    Author: Hanein D, Volkmann N, Goldsmith S, Michon AM, Lehman W, Craig R, DeRosier D, Almo S, Matsudaira P.
    Journal: Nat Struct Biol; 1998 Sep; 5(9):787-92. PubMed ID: 9731773.
    Abstract:
    Using a new procedure that combines electron-density correlation with biochemical information, we have fitted the crystal structure of the N-terminal actin-binding domain of human T-fimbrin to helical reconstructions of fimbrin-decorated actin filaments. The map locates the N-terminal calcium-binding domain and identifies actin-binding site residues on the two calponin-homology domains of fimbrin. Based on this map, we propose a model of a fimbrin crosslink in an actin bundle and its regulation by calcium.
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