These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of maternal infusion of adrenocorticotrophin1-24 (ACTH1-24) on parturition in guinea-pigs near term.
    Author: Schellenberg JC.
    Journal: Reprod Fertil Dev; 1997; 9(8):811-4. PubMed ID: 9733065.
    Abstract:
    While the mechanism of onset of labour in guinea-pigs is unknown, it has been suggested that administration of adrenocorticotrophin1-24 (ACTH1-24) near term induces labour. In order to verify this finding, guinea-pigs were fitted with indwelling carotid and jugular vascular cannulae. ACTH1-24 (30 microg h(-1) for four hours, n = 9) or vehicle (n = 5) was infused intravenously on Day 64 (term is 68 days). ACTH1-24 had no effect on gestational length (68.4+/-1.0 days, n = 6 v. control, 69.6+/-0.3 days, n = 5, P = 0.8). Symphysial width, fetal weight, number and viability were similar in both groups (all P > 0.1). Infusion of ACTH1-24 increased maternal ACTH concentrations from <1.8 pmol L(-1) to 34+/-6 pmol L(-1) (n = 6, P < 0.01) while fetal ACTH concentrations remained undetectable (n = 6). Infusion of ACTH1-24 increased cortisol concentrations in maternal plasma from 8.3+/-0.6 mmol L(-1) to 15.8+/-0.8 mmol L(-1) (n = 6, P < 0.001) but had no effect on concentrations of 13,14-dihydro-15-keto-PGF2alpha (P = 0.8). It is concluded that (1) maternal infusion of ACTH1-24 at the dosage used does not induce labour in guinea-pigs, and (2) ACTH1-24 does not cross the placenta.
    [Abstract] [Full Text] [Related] [New Search]