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  • Title: Functioning and nonfunctioning adrenocortical carcinoma: clinical presentation and therapeutic strategies.
    Author: Demeure MJ, Somberg LB.
    Journal: Surg Oncol Clin N Am; 1998 Oct; 7(4):791-805. PubMed ID: 9735134.
    Abstract:
    Adrenocortical cancers are relatively rare endocrine tumors that usually present when hormonally active or after they have become large and metastasis has occurred. Consequently, the 5-year survival rate is 20% to 35%. Surgical removal remains the only form of therapy proven to prolong survival. Mitotane is the most accepted form of chemotherapy. For the approximately 20% to 25% of patients whose tumors respond to mitotane, survival is prolonged.
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