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  • Title: Immunoblastic lymphadenopathy. Evolution into a malignant lymphoma with plasmacytoid features.
    Author: Fisher RI, Jaffe ES, Braylan RC, Andersen JC, Tan HK.
    Journal: Am J Med; 1976 Oct; 61(4):553-9. PubMed ID: 973649.
    Abstract:
    In the patient described progressive lymphadenopathy, splenomegaly and interstitial pulmonary disease developed two months after the development of immunoblastic lymphadenopathy. Light microscopic examination of a lymph node biopsy specimen suggested a diagnosis of immunoblastic sarcoma. Evolution of this malignant lymphoma into a leukemic phase allowed detailed studies of the malignant cells by electron microscopy, cytochemical staining and immunologic technics. Evidence is presented that this is a case of malignant lymphoma with plasmacytoid and not lymphoid features. Review of the literature on immunoblastic sarcoma suggests that light microscopy and clinical setting are not sufficient to define a homogeneous clinicopathologic disease.
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