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  • Title: trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound.
    Author: Vítolo MJ, Márquez VE, Hurtado I.
    Journal: J Med Chem; 1978 Jul; 21(7):692-4. PubMed ID: 97384.
    Abstract:
    The synthesis and antiallergic activity of a new heterocyclid steroidal molecule are described. Compound 1 was shown to inhibit the rat passive cutaneous anaphylaxis and its activity in this system was compared to that of disodium cromoglycate. It is orally active at a dose of 35 mg/kg (ED50) and its activity persists for up to 6 h for larger doses.
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