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  • Title: [Effectiveness of continuous intravenous prostaglandin E 1 against pulmonary hypertension].
    Author: Satomi K, Satoh T, Kyotani S, Fukushima S, Okano Y, Nakanishi N, Kunieda T.
    Journal: Nihon Kokyuki Gakkai Zasshi; 1998 May; 36(5):421-7. PubMed ID: 9742857.
    Abstract:
    Pulmonary hypertension is a progressive disease for which no effective therapy has been found. Short-team treatment with alprostadil alfadex (PGE 1) can improve hemodynamics but the effects of long-term treatment have not been reported. We administered intravenous PGE 1 to 16 patients with pulmonary hypertension for 4 weeks in addition to conventional therapy. Hemodynamic and symptomatic effects were evaluated. The infusion was interrupted in 7 patients (44%) because of fever and an increase in levels of C-reactive protein in serum. In the remaining 9 patients, the drug lowered pulmonary artery pressure and resistance, and imareased cardiac output significantly in 7 patients. PGE 1 can improve hemodynamics and relieve symptoms in patients with pulmonary hypertension, barring severe side effects.
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