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  • Title: Fertilization defects in sperm from mice lacking fertilin beta.
    Author: Cho C, Bunch DO, Faure JE, Goulding EH, Eddy EM, Primakoff P, Myles DG.
    Journal: Science; 1998 Sep 18; 281(5384):1857-9. PubMed ID: 9743500.
    Abstract:
    Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.
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