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  • Title: [The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases].
    Author: Beltinger C, Böhler T, Schrappe M, Ludwig WD, Debatin KM.
    Journal: Klin Padiatr; 1998; 210(4):153-8. PubMed ID: 9743945.
    Abstract:
    CD95 (APO-1/Fas)-mediated apoptosis plays a major role in normal lymphocyte regulation. CD95 mutations cause a benign autoimmune lymphoproliferation syndrome (ALPS) in mice and humans. CD95 is mutated in some de novo T-lineage acute lymphoblastic leukemia of childhood and these mutations might be of biological significance. The resistance toward CD95-mediated apoptosis observed in most B-lineage ALL is not caused by mutations of CD95. CD95 mutations have been associated with Hodgkin's and Non-Hodgkin's lymphoma and have been described in multiple myeloma. The relevance of CD95 mutations for chemoresistance of ALL requires further study.
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