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  • Title: Long-term low-dose co-trimoxazole in prophylaxis of childhood urinary tract infection: clinical aspects.
    Author: Smellie JM, Grüneberg RN, Leakey A, Atkin WS.
    Journal: Br Med J; 1976 Jul 24; 2(6029):203-6. PubMed ID: 974492.
    Abstract:
    Long-term low-dosage prophylaxis may be used in children with recurrent urinary tract infection to prevent reinfection of the urinary tract while the underlying cause of infection persists. Co-trimoxazole in a dose of 2 mg trimethoprin combined with 10 mg sulphamethoxazole per kg body weight daily has proved very effective: only six of 130 children receiving this treatment during a total period of 2637 months developed a reinfection. Co-trimoxazole was acceptable, compliance was good, and there were no important adverse effects. Supportive measures during prophylaxis are important. Sixty-five children were follow up after completion of their co-trimoxazole prophylaxis. Twenty-seven developed reinfections with fresh organisms, over two-thirds occurring within three months of discontinuing prophylaxis. Each one of these reinfections was sensitive to trimethoprin. The rectal flora were similarly sensitive.
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