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  • Title: Carcinomatous infiltration into the submucosa as a predictor of lymph node involvement in early gastric cancer.
    Author: Ishigami S, Hokita S, Natsugoe S, Tokushige M, Saihara T, Iwashige H, Aridome K, Aikou T.
    Journal: World J Surg; 1998 Oct; 22(10):1056-9; discussion 1059-60. PubMed ID: 9747166.
    Abstract:
    The clinicopathologic features of 114 patients with resectable early gastric cancer (EGC) invading the submucosa were examined retrospectively with respect to lymph node involvement and the possibility of performing a minimally invasive operation. Patients were divided into node-positive (n = 25) and node-negative (n = 81) groups. Among several pathologic factors, the diameter of the tumor and lymphatic involvement were significantly correlated with nodal involvement. Within the submucosal layer the depth of invasion and the horizontal cancerous expansion also correlated with lymph node disease (p < 0.05). The size of the tumor did not correlate with the length of submucosal infiltration (r = 0.12, p = 0.1). Patients with both slight invasion into the submucosa and less than 5 mm of horizontal expansion were often negative for lymph node involvement and thus may benefit from local surgery as an alternative to gastrectomy.
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