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  • Title: Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.
    Author: Arawaka S, Saito Y, Murayama S, Mori H.
    Journal: Neurology; 1998 Sep; 51(3):887-9. PubMed ID: 9748051.
    Abstract:
    In familial PD, a mutation of the alpha-synuclein gene has been identified. Alpha-synuclein also was revealed in Lewy bodies in idiopathic PD. Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer's disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.
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