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  • Title: Induction of type B virions to bud into cytoplasmic vacuoles in a mammary tumor of an X-ray- and urethan-treated X/Gf mouse.
    Author: Goldfeder A.
    Journal: Cancer Res; 1976 Nov; 36(11 Pt 1):4190-4. PubMed ID: 975056.
    Abstract:
    Electron microscopic studies of thin sections of a mammary carcinoma that developed in a female mouse of the syngeneic X/Gf low-cancer strain after treatments with X-rays (3 X 100 rads weekly) followed by 8 weekly i.p. injections of urethan (1 mg/g body weight) revealed extensive budding of B particles into cytoplasmic vacuoles and numerous characteristic B virions in the vacuolar lumens. Simultaneous budding of B particles into cytoplasmic vacuoles and budding of B particles at plasma membranes of the same cancer cell were also noted (figs. 2 to 6).
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