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  • Title: Experience with lyophilized human dura mater for urethral strictures.
    Author: Villavicencio Mavrich H, Moreno RP, Sariol JC, Briones JR, Bordes AR, Rodríguez JV.
    Journal: J Urol; 1998 Oct; 160(4):1310-1. PubMed ID: 9751342.
    Abstract:
    PURPOSE: We report our results using lyophilized human dura mater for urethral strictures. MATERIALS AND METHODS: The results of 131 urethroplasties using lyophilized human dura mater grafts were reviewed. The etiology of the stricture was unknown in most cases and 44.3% had not been previously treated. Mean stricture length was 10 cm. A dura mater patch was used in 124 cases and tubular graft in 7. RESULTS: Average followup was 56.6 months. The overall complication rate during the first month was 16.3%. At 6 months the graft failed in 2 cases and 25.2% had stricture recurrence. Good results were obtained in the longer term in 41.1% of cases, with a high recurrence rate and malignancy in 4 cases (3.2%) which required penectomy. CONCLUSIONS: Despite being a biologically well tolerated material, lyophilized human dura mater is not good for urethral strictures because of the high number of relapses and possibility of malignancy.
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