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  • Title: Blood transfusion and postoperative serum interleukin-6 levels in colorectal cancer patients.
    Author: Ishijima N, Suzuki H.
    Journal: Hepatogastroenterology; 1998; 45(22):1011-3. PubMed ID: 9755998.
    Abstract:
    BACKGROUND/AIMS: Postoperative cytokine response affects various factors. However, excessive stress responses are deleterious as increased serum concentration of cytokines may induce tissue injury and an impaired immune system. METHODOLOGY: We determined serum IL-6 levels in 35 patients who had undergone resection of colorectal carcinoma. Eleven patients had a blood transfusion before or during the operation (transfused group) but 24 patients had received no blood transfusion (control group). Serum IL-6 levels were determined before the operation, and at the end of operation,POD-1, 3, and 7. RESULTS: There was no significant difference of preoperative mean levels of IL-6 between these two groups (p=0.20). Postoperative serum IL-6 levels were significantly elevated. Mean serum levels of IL-6 were significantly higher at the end of operation in the transfused group than in the control group (131.7 pg/ml in control group and 269.8 pg/ml in transfused group; p=0.02). CONCLUSION: The present study suggested that perioperative allogeneic blood transfusion can induce an excessive cytokine response and may be deleterious.
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