These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The wst gene regulates multiple forms of thymocyte apoptosis.
    Author: Potter M, Bernstein A, Lee JM.
    Journal: Cell Immunol; 1998 Sep 15; 188(2):111-7. PubMed ID: 9756641.
    Abstract:
    Mice homozygous for the autosomal recessive mutation Wasted (wst/wst) display a disease characterized by immunodeficiency, cerebellar dysfunction, and sensitivity of their hematopoeitic cells to gamma radiation. Wasted mice die by 30 days of age. In this report, we show that the Wasted thymus shows evidence of dramatically increased apoptosis in situ. Moreover, wst/wst thymocytes are more sensitive to apoptosis induced by gamma radiation, heat shock, alpha-CD3 stimulation, and dexamethasone treatment in vitro. Thus, wst gene is a regulator of thymocyte apoptosis both in vitro and in vivo. The elevated levels of thymocyte apoptosis may be a major contributor to the lymphoid dysfunction and ultimate death in wst/wst mice.
    [Abstract] [Full Text] [Related] [New Search]