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  • Title: Structural features of the aldose reductase and aldehyde reductase inhibitor-binding sites.
    Author: El-Kabbani O, Wilson DK, Petrash M, Quiocho FA.
    Journal: Mol Vis; 1998 Sep 29; 4():19. PubMed ID: 9756955.
    Abstract:
    The three-dimensional structures of aldose reductase and aldehyde reductase, members of the aldo-keto reductase superfamily, are composed of similar alpha/beta TIM-barrels. However, examination of the structures reveals that the inhibitor-binding site of aldose reductase differs from that of aldehyde reductase due to the participation of non-conserved residues in its formation. This information will be useful in the design of inhibitors to prevent or delay diabetic retinopathy. A review of the structures of the inhibitor-binding sites is presented.
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