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  • Title: Inhibition by alanine of AMP-deaminase from rabbit skeletal muscle.
    Author: Kaletha K, Skladanowski A, Zydowo M.
    Journal: Acta Biochim Pol; 1976; 23(2-3):145-50. PubMed ID: 9758.
    Abstract:
    1. Alanine inhibits rabbit muscle AMP-deaminase while aspartate, histidine and glutamate are ineffective. 2. The degree and type of inhibition of AMP-deaminase by alanine depend on pH; at pH 6.5 alanine behaves like an allosteric effector exerting a negative heterotropic effect. At pH 7.0 the inhibition is non-competitive, Ki being as high as 19 mM. 3. The probable significance of the effect of alanine on AMP-deaminase in muscle metabolism is discussed.
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