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  • Title: [Association between the debrisoquine hydroxylase gene polymorphism and the genetic susceptibility of Parkinson's disease].
    Author: Tao E, Liu Z, Chen B, Pan X, Shao M.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 1998 Oct 10; 15(5):281-3. PubMed ID: 9758873.
    Abstract:
    OBJECTIVE: To clarify the relation of the debrisoquine hydroxylase gene polymorphism with the genetic susceptibility of Parkinson's disease. METHODS: The debrisoquine hydroxylase gene polymorphisms were analyzed with the polymerase chain reaction-restriction fragment length polymorphism methods in 100 cases of Parkinson's disease and 100 age-,sex-matched normal controls. RESULTS: It was found that the frequencies of A and B mutation of debrisoquine hydroxylase gene in group of patients were higher than those in the controls, and the risk of suffering Parkinson's disease increased 2 times. In group of the patients, the frequencies of C188-->T, G4268-->C and C2938-->T were also higher than those in the controls. Especially in those with C2938-->T mutation, the risk of suffering the disease increased 2.58 times. CONCLUSION: The result suggested that the defect of the detoxifying enzymes might be a factor contributing to the genetic susceptibility of Parkinson's disease.
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