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  • Title: Pre-exposure to alcohol does not sensitize to the rewarding effects of cocaine.
    Author: Le Pen G, Duterte-Boucher D, Daoust M, Costentin J.
    Journal: Neuroreport; 1998 Aug 24; 9(12):2887-91. PubMed ID: 9760140.
    Abstract:
    The conditioned place preference (CPP) induced by cocaine 2.5 mg/kg was measured in rats pre-exposed to ethanol (14 days with only 10% v/v ethanol followed by a free choice between ethanol solution and water for 14 days). Rats were divided according to their alcohol intake during the free choice period into low-drinking (<3 g/kg per day), intermediate-drinking and high-drinking (> 4 g/kg per day) rats. Cocaine-induced CPP was not modified in high-drinking rats relative to controls. Low-drinking rats had a lower CPP than high-drinking rats and controls. We conclude that pre-exposure to alcohol did not sensitize to the cocaine rewarding effects, and that alcohol low-drinking rats showed the lowest preference for cocaine.
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