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  • Title: Opposite effects of spironolactone and amiloride on potassium excretion in a patient with ascites due to liver cirrhosis.
    Author: Radó JP, Juhos E.
    Journal: Endokrinologie; 1976 Jul; 67(3):377-9. PubMed ID: 976213.
    Abstract:
    Potassium excretion was enhanced by spironolactone and it was inhibited by amiloride in a patient with ascites. One drug's effect was counteracted by the other when they were used in combination. Individual variation in the sites of action of antikaluretic drugs might be a possible explanation for the unpredictable changes in potassium excretion induced by these agents.
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