These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Acute renal failure in the course of occupational lead intoxication. Chelation therapy responsability (author's transl)].
    Author: Yver L, Maréchaud R, Picaud D, Touchard G, d'Eyzac AT, Matuchansky C, Patte D.
    Journal: Nouv Presse Med; 1978 May 06; 7(18):1541-3. PubMed ID: 97624.
    Abstract:
    In a patient with occupational plumbism and a normal kidney function, EDTA therapy (1 g/24 h) resulted in a massive lead excretion (15 000 microgram/24 h) together with acute renal failure. A direct nephrotoxic effect of EDTA was excluded: after renal function returned to normal, EDTA could be subsequently readministered at progressively increasing doses (250 mg to 1 g/24 h) without any renal dysfunction. These findings strongly suggest a close relationship between the burden of lead mobilized by EDTA and the acute renal failure. This case can be classified as acute lead nephropathy of which only a few instances have been reported in the literature. The interest of monitoring lead excretion during chelation therapy is particularly emphasized.
    [Abstract] [Full Text] [Related] [New Search]