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  • Title: Synthesis of some new benzimidazolecarboxamides and evaluation of their antimicrobial activity.
    Author: Göker H, Tunçbilek M, Ayhan G, Altanlar N.
    Journal: Farmaco; 1998 Jun 30; 53(6):415-20. PubMed ID: 9764474.
    Abstract:
    A series of 1,2-disubstituted benzimidazole-5(6)-carboxamides was prepared and evaluated in vitro for antimicrobial activity against Staphyloccus aureus, Escherichia coli and Candida albicans. The precursor benzimidazolecarboxylic acids 4a-c and 9a-c were prepared via oxidative condensation of diaminobenzoic acids with aldehydes and via several steps over the 2(1H)-benzimidazolones, respectively. All acids were converted to their acyl chlorides with SOCl2, then amidified with several N,N'-dialkylaminoethyl derivatives. Compounds 8a-c, 20 and 22 exhibited the best activity.
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