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  • Title: [Mixed corticomedullary tumor].
    Author: Delèvaux I, Cabane J, Picard O, Bénit C, Lebas J, Nordlinger B, de Saint-Maur P, Imbert JC.
    Journal: Presse Med; 1998 Sep 05; 27(25):1272-4. PubMed ID: 9765645.
    Abstract:
    BACKGROUND: Pheochromocytoma and primary hyperaldosteronism rarely occur simultaneously. Few cases have been reported in the literature. CASE REPORT: A patient explored for hypertension was found to have hypokalemia related to primary hyperaldosteronism. Pathology examination of the ablated adrenal showed a co-existing pheochromocytoma suspected at history taking although urine catecholamines were normal. DISCUSSION: Different pathogenic hypothesis have been proposed. Such dual tumors could be a simple coincidence, occur in a particular genetic setting, be related to direct contact between cortical and medullary tissue leading to reactional cortical hyperplasia, pheochromocytoma produced factors stimulating aldosterone synthesis, or factor X, a substance produced by cortical adenomas and favoring growth of the pheochromocytoma.
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