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  • Title: The pathogenesis of HLA-B27 arthritis: role of HLA-B27 in bacterial defense.
    Author: Ikeda M, Yu DT.
    Journal: Am J Med Sci; 1998 Oct; 316(4):257-63. PubMed ID: 9766487.
    Abstract:
    The way in which a host accommodates invasive facultative intracellular bacteria must be the key to the development of reactive arthritis. Investigators have analyzed the bacterial events at several levels: invasion into host cells, intracellular survival, translocation from the sites of infection to the joints, residence in the joints, and evasion of host defense. Because HLA-B27 is present in higher incidence in patients with reactive arthritis and is an essential gene in the related ankylosing spondylitis, the role of HLA-B27 in host defense is also assumed to be important in the development of reactive arthritis. This review summarizes the various studies in this field.
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