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  • Title: [Comparison of labour induction with intravenous prostaglandin E2 and intravenous oxytocin (author's transl)].
    Author: Steiner H, Weitzel R, Zahradnik HP.
    Journal: Geburtshilfe Frauenheilkd; 1976 Sep; 36(9):773-7. PubMed ID: 976723.
    Abstract:
    Based on our results we are able to attribute to the PGE2 a special importance during the beginning of cervical dilatation. A cervical dilatation up to 3 cm is faster achieved by cervical relaxation effect and a direct effect on myometrial tissue independant from exterior parameters. The earlier the cervix has reached such a dilatation, the earlier regular contractions are registered at inductions with PGE2. These contractions are furthermore more effective and led to a shorter induction delivery interval under a minimal physiologic stress. This procedure is combined to a lower intrauterine pressure and shows no negative sideeffects on child and mother. Oxytocin and PGE2 (prostaglandin D 2) were administered to 2 groups of 20 women, 40 weeks pregnant, in order to induce labor. Labor duration was significantly shorter in the PGE2 group (2 hrs., 36 mins.) than among the oxytocin group (3 hrs., 26 mins.). The peak uterine pressure for PGE2 patients was significantly lower; the baseline uterine pressure was significantly greater, indicating more even labor contractions. There was a highly significant correlation between the interval from administration to the initial contraction and the total labor duration (p .005) and between the interval from administration to the beginning of regular contractions and the total labor duration (p .01) among the PGE2 patients. There was also a highly significant correlation (p .01) between the dosage/kg until the initial contraction and the total pregnancy duration and between the dosage/kg until the beginning of regular contractions and the total pregnancy duration for PGE2 patients. PGE2 patients showed a significantly faster cervical dilation (.05 p .1) and a significantly shorter interval between dilatation and delivery (p .05). PGE patients also showed a significantly shorter interval between the initial contractions and delivery and between the beginning of regular contractions and delivery. Also, a significant correlation between cervical dilatation and delivery was demonstrated among PGE2 patients. A significant correlation between cervical dilatation and the beginning of contractions was established only for oxytocin patients.
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