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  • Title: [The relationship between insulin resistance and abnormalities of cellular calcium metabolism and cell membrane abnormalities in patients with essential hypertension].
    Author: Fu Y, Wang S, Lu Z.
    Journal: Zhonghua Yi Xue Za Zhi; 1997 Jun; 77(6):443-6. PubMed ID: 9772510.
    Abstract:
    OBJECTIVE: To investigate the relationship between the insulin resistance (IR) and the abnormalities of cellular calcium metabolism and cell membrane in patients with essential hypertension. METHODS: Plasma insulin and glucose before and during OGTT, membrane ATPase activity, cholesterol (C) and phospholipid (P), lipid peroxides (MDA), intracellular total calcium concentration [(Ca2+)i] and calcium binding capacity of inner surface of membranes were determined in 26 normotensive (NT) subjects, 17 hypertensives (HT), and 16 hypertensives associated with IR (HT + IR). RESULTS: The HT + IR group had higher levels of plasma glucose and insulin than that in the NT group and HT group with significant differences. The HT + IR group consistently demonstrated depressed activity of each Na(+)-K(+)-ATPase and Ca(2+)-ATPase studied with significant differences when compared with the NT group, but no difference was found if compared with the HT group. There was a higher [(Ca2+)i] in the HT + IR group than those in the NT group and even in the HT group with significant differences, respectively. Insulin sensitivity in the HT + IR group was significantly lower than that in both groups of HT and NT, respectively. The membrane C/P molar ratio and MDA content in the HT + IR group and HT group were significantly higher than those in the NT group, respectively. CONCLUSIONS: It is likely that there is a causal relation between IR and abnormalities of cellular calcium metabolism and membrane lipids in patients with essential hypertension.
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