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  • Title: [Study on the mitoxantrone ethylcellulose microspheres for liver artery embolization].
    Author: Zhang ZR, Wang D, Liao FY, Liao GT.
    Journal: Yao Xue Xue Bao; 1996; 31(8):626-31. PubMed ID: 9772711.
    Abstract:
    In this paper, orthogonal test was used to optimize the preparation conditions and technique of mitoxantrone ethylcellulose microspheres (DHAQ-EC-MS) for liver embolization. The dynamic osmosis method was used to study the drug release characteristics of DHAQ-EC-MS. DHAQ-EC-MS suspension for clinical liver artery embolization was prepared. The result showed that the DHAQ-EC-MS is regular in its morphology with a mean diameter of 110.24 +/- 38.19 microns. The drug loading was 12.5% and embedding ratio was 55.6%. The release characteristics was in accord with single exponential model. The drug release equation is lg(Yinfinity - Y) = -0.116t - 1.198 x 10(-3) (gamma = 0.9992, t50 = 2.6 h). The DHAQ-EC-MS was shown to be physically and chemically stable and its suspension is suitable for clinical use. Experiments in dogs indicate that drug concentration of DHAQ-EC-MS in hepatic vein blood was higher than DHAQ solution, and the MRT0-72 was 2.45 times higher than DHAQ solution.
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