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  • Title: Efficacy of albendazole against Giardia and hookworm in a remote Aboriginal community in the north of Western Australia.
    Author: Reynoldson JA, Behnke JM, Gracey M, Horton RJ, Spargo R, Hopkins RM, Constantine CC, Gilbert F, Stead C, Hobbs RP, Thompson RC.
    Journal: Acta Trop; 1998 Aug 15; 71(1):27-44. PubMed ID: 9776141.
    Abstract:
    The parasitological, clinical efficacy and tolerability of albendazole in the treatment for both giardiasis and hookworm infection in a remote Aboriginal population was investigated. Albendazole at a dose rate of 400 mg daily for 5 days was highly effective in reducing hookworm egg numbers and both Giardia antigen and cysts. The 36.6% prevalence of Giardia prior to treatment fell to 12% between days 6 and 9, 15% for days 10-17 and rose to 28% between days 18 and 30. Tolerability and clinical efficacy were excellent. The effect of albendazole on hookworm was longer lasting than that on Giardia, reducing percent infection from over 76-2% on days 6-9 and zero by day 18-30 despite conditions highly conducive to rapid re-infection. We conclude that albendazole is highly efficacious against both parasites when used as described but that long term community benefit may require additional education programmes to avoid re-infection with Giardia although treatment strategies would seem appropriate for hookworm.
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