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  • Title: [Comparison of the effect of desflurane with isoflurane in patients over 65 years of age: multicenter study].
    Author: Canet J, Roigé J, Bandrés R, Campos JM, Chiveli MA, Campbell J.
    Journal: Rev Esp Anestesiol Reanim; 1998; 45(7):280-4. PubMed ID: 9780764.
    Abstract:
    OBJECTIVE: To compare the effects of desflurane (DES) and isoflurane (ISO) in patients over 65 years of age based on recovery, hemodynamic variables, need for additional drugs and postoperative rates of nausea and vomiting. PATIENTS AND METHODS: Ninety-eight patients were anesthetized with DES (n = 51) at an inspired concentration of 3% or ISO (n = 47) at a concentration of 0.5%, both combined with 60% nitrous oxide. Anesthetic concentration was later adjusted to maintain hemodynamic variables within 20% above or below baseline. Analgesia was provided with fentanyl and neuromuscular relaxation with atracurium. After surgery, anesthetic gases were withdrawn. We then recorded variables related to anesthetic recovery, postoperative analgesia and the rates of nausea and vomiting. RESULTS: Mean time (+/- SD) until eye opening was 7.6 +/- 5.5 minutes for patients anesthetized with DES and was significantly less than the 14.4 +/- 8.9 minutes taken by patients anesthetized with ISO (p < 0.01). Patients anesthetized with DES spent 23 minutes less time in the recovery room than did patients anesthetized with ISO (p < 0.05). There were no significant differences in need for fentanyl, atracurium, postoperative analgesia, hemodynamic variables or rates of nausea or vomiting. CONCLUSIONS: Patients over 65 years of age anesthetized with DES recovered in half the time of patients anesthetized with ISO. DES is a safe anesthetic for elderly patients and may offer clinical advantages.
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