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  • Title: Serum follicle-stimulating hormone, luteinizing hormone and progesterone concentrations in pseudopregnant rats treated with medroxyprogesterone acetate.
    Author: de Greef WJ, Dullaart J, Zeilmaker GH.
    Journal: J Endocrinol; 1976 Sep; 70(3):465-71. PubMed ID: 978105.
    Abstract:
    Pseudopregnant rats were treated early in pseudopregnancy with 1 or 10 mg medroxyprogesterone acetate (MPA). Serum FSH, LH and progesterone concentrations were determined on days 2-20 of pseudopregnancy in treated and control rats. The mean duration of pseudopregnancy was 13-5 days in the control animals, but when animals were treated with 1 mg MPA a dioestrous period of 21-4 days was observed. A period with leucocytic vaginal smears of at least 2 months was observed after treatment with 10 mg MPA. Injection with MPA on day 3 of pseudopregnancy did not affect the serum FSH concentrations during the subsequent days. The progesterone pattern was alike in the three groups of animals, i.e. the duration of the activity of the corpora lutea was similar in all groups. However, 10 mg MPA slightly lowered progesterone concentrations on days 4-8 of pseudopregnancy. In the saline-treated rats, LH concentrations decreased from days 2-5, and remained low until they increased after day 11 of pseudopregnancy. This increase was delayed until day 20 in the animals treated with 1 mg MPA, and was not observed in the animals treated with 10 mg MPA. It is argued that the increase of LH concentration at the end of pseudopregnency is not instrumental in the decrease of peripheral progesterone concentration but rather that the decrease in the progesterone concentration leads to the increase in the LH concentration. Concentrations of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), and progesterone (P) in pseudopregnant rats treated with medroxyprogesterone acetate (MPA) were measured to determine whether the increase in LH concentration seen is instrumental in the induction of the decrease in luteal progesterone secretion, which is associated with an increase in luteal 20alpha-hydroxyprogesterone secretion. Rats were treated with 1 or 10 mg MPA on the 3rd day of pseudopregnancy. FSH, LH, and P were determined on Days 2-20. Control animals had a 13.5 day mean for pseudopregnancy. Administration of 1 mg MPA sc resulted in a diestrous period of 21.4 days. Leukocytic vaginal smears were seen for 2 months when 10 mg MPA was given. FSH concentration was unaffected by the injection. P was similar for all 3 groups, with a slight depression seen in the high dose group from Day 4 to 8 of pseudopregnancy. In controls, LH decreased from Days 2 to 5 and then increased after Day 11. In animals treated at the low dose, this increase was delayed to Day 20 and it was absent in animals treated with 10 mg MPA. It is suggested that the increase in LH at the end of pseudopregnancy is initiated by the decrease in progesterone concentration.
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