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  • Title: Characterization of a heavy metal ion transporter in the lysosomal membrane.
    Author: Havelaar AC, de Gast IL, Snijders S, Beerens CE, Mancini GM, Verheijen FW.
    Journal: FEBS Lett; 1998 Oct 02; 436(2):223-7. PubMed ID: 9781683.
    Abstract:
    Lysosomes are thought to play a role in various aspects of heavy metal metabolism. In the present study we demonstrate for the first time the presence of a heavy metal ion transport protein in the lysosomal membrane. Uptake of radioactive silver both in highly purified lysosomal membrane vesicles and in purified intact lysosomes showed the typical kinetics of a carrier-mediated process. This transport was stimulated by ATP hydrolysis, and showed specificity for Ag+, Cu2+, and Cd2+. All biochemical properties of this lysosomal metal ion transporter could classify it as a heavy metal transporting P-type ATPase. Long Evans Cinnamon (LEC) rats, an animal model for the copper transport disorder Wilson disease, showed normal lysosomal silver transport.
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