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  • Title: Substrate specificity of the human coronavirus 229E 3C-like proteinase.
    Author: Ziebuhr J, Heusipp G, Seybert A, Siddell SG.
    Journal: Adv Exp Med Biol; 1998; 440():115-20. PubMed ID: 9782272.
    Abstract:
    Coronavirus gene expression involves proteolytic processing of the gene 1-encoded polyproteins and a key enzyme in this process is the virus-encoded 3C-like proteinase. In this study, we describe the biosynthesis of the human coronavirus 229E 3C-like proteinase in Escherichia coli and the substrate specificity of the purified protein. Using immunofluorescence microscopy, we have also investigated the subcellular localization of the 3C-like proteinase and have found a punctate, perinuclear distribution of the proteinase in virus-infected cells.
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