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  • Title: Morphological aspects of the elimination of polyneuronal innervation of skeletal muscle fibres in newborn rats.
    Author: Korneliussen H, Jansen JK.
    Journal: J Neurocytol; 1976 Oct; 5(8):591-604. PubMed ID: 978234.
    Abstract:
    The ultrastructure of neuromuscular junctions of rat soleus muscles 1-40 days postnatally was examined for possible morphological correlates of the transient polyneuronal innervation which is present in newborn rats. Several vesicle-laden profiles of terminal axons are seen to contact each muscle fiber up to 8 days postnatally. Axon terminals often lie close together, without Schwann cell intervention. Between days 8 and 16 the number of profiles of terminals on each muscle fibre is reduced, and both Schwann cells and ridge-like extensions of muscle fibre cytoplasm intervene between and separate axon terminals. No signs of degenerating intramuscular axons or axon terminals could be found. It is suggested that the redundant terminals are eliminated by retraction into the parent axons. This process is apparently accomplished without any morphological signs of degeneration.
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