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  • Title: Technetium-99m labeling of human monocytes for chemotactic studies.
    Author: Papierniak CK, Bourey RE, Kretschmer RR, Gotoff SP, Colombetti LG.
    Journal: J Nucl Med; 1976 Nov; 17(11):988-92. PubMed ID: 978262.
    Abstract:
    Although the current use of 51Cr for the evaluation of monocyte chemotaxis has yielded encouraging results, certain properties of this radionuclide leave room for improvement. Technetium-99m was evaluated as an alternative label for this purpose. A cell loss of 50% was found, but the recovered cells showed excellent viability and function. Chemotaxis was measured using a modified Boyden's chamber and a lymphocyte-derived chemotactic factor. The chemotactic properties of 99mTc-labeled human monocytes were preserved, and an excellent correlation between radioactive measurement and microscopic counting of migrating cells was observed.
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