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  • Title: Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome.
    Author: Coakley G, Mok CC, Hajeer AH, Ollier WE, Turner D, Sinnott PJ, Hutchinson IV, Panayi GS, Lanchbury JS.
    Journal: Br J Rheumatol; 1998 Sep; 37(9):988-91. PubMed ID: 9783765.
    Abstract:
    OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions.
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