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  • Title: Odontogenic fibroma in Sprague-Dawley rats: a report of 2 cases.
    Author: Ernst H, Scampini G, Durchfeld-Meyer B, Brander-Weber P, Rittinghausen S.
    Journal: Exp Toxicol Pathol; 1998 Sep; 50(4-6):384-8. PubMed ID: 9784012.
    Abstract:
    Two cases of odontogenic fibroma occurring in aged Sprague-Dawley rats are described. Both neoplasms were associated with a maxillary incisor and had identical histomorphological features. They were composed of solid proliferations of primitive, dental pulp-like mesenchyme separated by areas of collagenization. Small strands and islands of mainly undifferentiated odontogenic epithelium immunostaining for keratins were scattered throughout both tumours. As a further characteristic, the lesions contained small foci of mineralization which were either cementum-like or resembled dysplastic dentin. The odontogenic fibroma represents a further type of odontogenic tumour in rats, which due to its typical histomorphology, can easily be differentiated from other odontogenic tumours such as ameloblastic odontoma or ameloblastoma.
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