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  • Title: A new series of S-adenosyl-L-methionine synthetase inhibitors.
    Author: Lavrador K, Allart B, Guillerm D, Guillerm G.
    Journal: J Enzyme Inhib; 1998 Aug; 13(5):361-7. PubMed ID: 9793839.
    Abstract:
    A new series of epithio and epoxy amino acid analogues of L-methionine or L-methoxinine were examined as potential inhibitors of the enzyme S-adenosylmethionine (AdoMet) synthetase. The kinetic behaviour of these compounds was studied using recombinant rat liver S-adenosyl-L-methionine sythetase (alpha-isoform) fractionated from E. coli, transformed with the plasmid pSSRL-T7N. All the compounds tested were competitive inhibitors with respect to L-methionine and the (2S, 4S)-2-amino-4,5-epoxy pentanoic acid was found to be a very potent inhibitor of the enzyme compared to those already reported for AdoMet synthetase from other mammalian tissues.
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