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  • Title: Hypoxia-inducible factor 1: master regulator of O2 homeostasis.
    Author: Semenza GL.
    Journal: Curr Opin Genet Dev; 1998 Oct; 8(5):588-94. PubMed ID: 9794818.
    Abstract:
    Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.
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