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  • Title: The use of antibodies against the IL-2 receptor in transplantation.
    Author: Waldmann TA, O'Shea J.
    Journal: Curr Opin Immunol; 1998 Oct; 10(5):507-12. PubMed ID: 9794841.
    Abstract:
    Humanized monoclonal antibodies that recognize the alpha chain of the IL-2 receptor (e.g. daclizumab) have been used to prevent allograft rejection, since this chain is expressed by T cells participating in allograft rejection but not by resting T cells. In a randomized trial, when added to standard cyclosporin-based immunosuppression, daclizumab significantly reduced the frequency of acute rejection of renal transplants.
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