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  • Title: Up-regulation of thioredoxin expression in motor neurons after nerve injury.
    Author: Mansur K, Iwahashi Y, Kiryu-Seo S, Su Q, Namikawa K, Yodoi J, Kiyama H.
    Journal: Brain Res Mol Brain Res; 1998 Nov 12; 62(1):86-91. PubMed ID: 9795155.
    Abstract:
    A substantial up-regulation of thioredoxin, a dithiol/disulfide oxido-reductase, in adult rat motoneurons following hypoglossal nerve axotomy, was demonstrated by using both in situ hybridization and immunohistochemistry. Although thioredoxin is normally accumulated more in the nucleus of a motoneuron rather than in the cytoplasm, a dramatic increase of thioredoxin in the cytoplasmic region after nerve injury was observed. The up-regulation of mRNA lasted more than 9 weeks, whereas, the detectable up-regulation of protein was observed for more than 5 weeks.
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