These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Removal of hydroxyl radical facilitates Ca2+-dependent [3H]GABA release by peroxynitrite.
    Author: Higo A, Katsura M, Hibino Y, Hara A, Tarumi C, Ohkuma S.
    Journal: Brain Res Mol Brain Res; 1998 Nov 12; 62(1):96-100. PubMed ID: 9795162.
    Abstract:
    We investigated mechanisms for enhancement of peroxynitrite (OONO-; 5 microM)-evoked [3H] gamma-aminobutyric acid (GABA) release. Hydroxyl radical scavengers such as N,N'-dimethylthiourea (DMTU), mannitol, and uric acid, significantly increased OONO--evoked [3H]GABA release, whereas urea showed no effects on the release. Removal of Ca2+ from incubation buffer abolished the enhancement of the release by DMTU, although DMTU showed no effects on the basal release with and without Ca2+ in extracellular space. These results indicate that hydroxyl radical scavengers facilitate OONO--evoked [3H]GABA release dependent on Ca2+.
    [Abstract] [Full Text] [Related] [New Search]