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  • Title: Biodegradation of biphenyl by the ascomycetous yeast Debaryomyces vanrijiae.
    Author: Lange J, Hammer E, Specht M, Francke W, Schauer F.
    Journal: Appl Microbiol Biotechnol; 1998 Sep; 50(3):364-8. PubMed ID: 9802222.
    Abstract:
    Cells of the yeast strain Debaryomyces vanrijiae SBUG 770, grown with glucose, converted biphenyl to 4-hydroxybiphenyl as the major metabolite. In addition, 2-hydroxybiphenyl was formed in minor amounts. No further degradation of these substances was detected. However, these monohydroxylated derivatives were oxidised by alkane-grown cells in the presence of the co-metabolic substrate, tetradecane. Under these conditions 2-hydroxybiphenyl was oxidised to 2,5-dihydroxybiphenyl, and 4-hydroxybiphenyl was rapidly metabolised by formation of two major metabolites. One was identified as 3,4-dihydroxybiphenyl. Characterisation of the second product as 4-phenylmuconolactone points to a further metabolism of the initially formed dihydroxylated biphenyl via ortho-ring fission.
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